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Australian Researchers Develop Nanoparticles to Enhance Immunotherapy for Breast Cancer

Nanotechnology

Business Honor
27 March, 2025

Researchers create iron-based nanoparticles to boost immune response against aggressive triple-negative breast cancer.

To improve current treatments for triple-negative breast cancer (TNBC) which is one of the most aggressive and deadly forms of the illness, Australian researchers are developing next-generation nanoparticles. To boost the body's immune response against TNBC, researchers are creating novel iron-based nanoparticles, or "nano-adjuvants," that are so tiny that thousands could fit on a single hair strand, the University of Queensland's Australian Institute for Bioengineering and Nanotechnology (AIBN) said Monday, according to the Xinhua news agency.

Prof. Yu Chengzhong of the AIBN explained that effective therapy for TNBC is challenging because it lacks the proteins targeted by conventional treatments used for other cancers, unlike other types of breast cancer.

Yu stated that despite the potential of immunotherapy, its effectiveness against triple-negative breast cancer is very limited, leaving many women without options, and their research aims to change that. According to Yu, the nanoparticles are intended to improve the immune system's capacity to identify and combat cancer cells by boosting the activity of T-cells and the white blood cells that the immune system uses to combat illness within the tumor microenvironment.

Yu, who has more than 20 years of experience in nanotechnology and Nano medicine, believes that this discovery will revolutionize cancer treatment by increasing the efficacy of immunotherapy for patients with aggressive solid tumors.

Alan Rowan, director of the AIBN, stated that this research will push scientific boundaries to develop innovative treatments, offering hope for women facing severe outcomes from this cancer.