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New DNA Nanostructures Allow Flexible and Stimuli-Responsive Condensates

Nanotechnology

Business Honor - Flexible DNA Condensates Advance Biotech

Business Honor
08 August, 2025

Researchers developed a new type of DNA nanostructure that offers flexibility, stability, and responsiveness for biomedical and bioengineering applications.

Researchers from Chuo University and the Institute of Science Tokyo developed a new type of DNA nanostructures that, without the need for chemical cross-linking, form flexible, stimuli-responsive condensates. This study was published in JACS Au, with a chance to completely change the way flexible soft substances are made for use in bioengineering, delivery of drugs, and artificial cells.

Inflexible, rectangular DNA nanostructures join in specific ways to create string-like structures that are the foundational elements of these new condensates. This anisotropic design allows the structures to connect physically instead of chemically, in contrast with earlier DNA designs that often use flexible patterns. The condensation also shows high fluidity and stable structure.

The study's main researcher, Professor Masahiro Takinoue, stated, "Our anisotropic rectangular DNA condensation provides an exciting new flexible material with possibilities for use over a wide range of areas, including bioengineering and artificial cell structures."

The team's studies suggest that these condensates have excellent mechanical properties. They can fit into extremely small channels and also stretch out into flexible shapes without breaking. This is exactly how natural biomolecular condensates operate in living cells, controlling vital processes like metabolism and expression of genes.

The DNA condensates are not only flexible but also sensitive to stimuli. In order to allow UV light to trigger breakdown and the release of single nanostructures, the researchers introduced photocleavable spacers to the DNA strands. In addition, the condensates showed structural changes due to the changes in temperature, raising the opportunity for controlled biological use.

It provides clarity on the effects of structural anisotropy on condensate behavior, an element that is often overlooked in artificial systems. Providing a foundation for the future development of stronger and more useful biomaterials by duplicating the complexity and flexibility of natural cells.